Phenethyl bromide → HCID 19606324, compound

HRID 1603909Notes

Reaction equation

HRID 1603909 reaction equation
[Cl:1][C:2]1[C:7]2[CH2:8][CH:9]([CH2:11]OS(C(F)(F)F)(=O)=O)[O:10][C:6]=2[CH:5]=[CH:4][C:3]=1[C:20]#[N:21].Br[CH2:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[Cl:1][C:2]1[C:7]2[CH2:8][CH:9]([CH2:11][CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[O:10][C:6]=2[CH:5]=[CH:4][C:3]=1[C:20]#[N:21]

Participants

3

Reactant 2

HCID 7666Phenethyl bromideHCID 19606279HCID 19606279, compound

Product 1

HCID 19606324HCID 19606324, compoundYield 68%

Procedure

Following the process described in example 3 (point B), starting from 4-chloro-2-trifluoromethanesulfonyloxymethyl-2,3-dihydrobenzofuran-5-carbonitrile and 2-bromoethylbenzene, the title compound was prepared, which was purified by chromatography through a silica gel column, eluting with petroleum ether:ethyl ether, 95:5 (68% yield).

Workup

  1. customwhich was purified by chromatography through a silica gel column
  2. washeluting with petroleum ether

Sources & evidence

ORD record
ord-738592f6c4004717be6457b69dab1987
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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