3-Amino-2-hydroxyacetophenone → HCID 19606359, compound

HRID 1603910Notes

Reaction equation

HRID 1603910 reaction equation
[Cl:1][C:2]1[C:7]2[CH2:8][CH:9]([CH2:11][CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:10][C:6]=2[CH:5]=[CH:4][C:3]=1[C:20]([OH:22])=O.[CH3:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([NH2:32])[C:27]=1[OH:33])=[O:25]>>[C:24]([C:26]1[C:27]([OH:33])=[C:28]([NH:32][C:20]([C:3]2[CH:4]=[CH:5][C:6]3[O:10][CH:9]([CH2:11][CH2:12][CH2:13][C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH2:8][C:7]=3[C:2]=2[Cl:1])=[O:22])[CH:29]=[CH:30][CH:31]=1)(=[O:25])[CH3:23]

Participants

3

Reactant 2

HCID 4592943-Amino-2-hydroxyacetophenoneHCID 19606312HCID 19606312, compound

Product 1

HCID 19606359HCID 19606359, compoundYield 93%

Procedure

Following the process described in example 1 (point K), starting from 4-chloro-2-(3-phenylpropyl)-2,3-dihydrobenzofuran-5-carboxylic acid and 3-amino-2-hydroxyacetophenone, the title compound was prepared (93% yield).

Sources & evidence

ORD record
ord-d531de93c4b246aca6aa5cb3275216c5
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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