Phenethyl bromide → HCID 19606267, compound

HRID 1603912Notes

Reaction equation

HRID 1603912 reaction equation
[Cl:1][C:2]1[C:19]([C:20]#[N:21])=[CH:18][C:5]2[CH2:6][CH:7]([CH2:9]OS(C(F)(F)F)(=O)=O)[O:8][C:4]=2[CH:3]=1.Br[CH2:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[Cl:1][C:2]1[C:19]([C:20]#[N:21])=[CH:18][C:5]2[CH2:6][CH:7]([CH2:9][CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[O:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 7666Phenethyl bromideHCID 19606309HCID 19606309, compound

Product 1

HCID 19606267HCID 19606267, compoundYield 20%

Procedure

Following the process described in example 3 (point B), starting from 6-chloro-2-trifluoromethanesulfonyloxymethyl-2,3-dihydrobenzofuran-5-carbonitrile and 2-bromoethylbenzene, the title compound was prepared, which was purified by chromatography through a silica gel column, eluting with petroleum ether:ethyl ether, 9:1 (20% yield).

Workup

  1. customwhich was purified by chromatography through a silica gel column
  2. washeluting with petroleum ether

Sources & evidence

ORD record
ord-c3cbf3ad82624a169266b37d199d261c
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

Loading…