HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Hydroxy-3-iodophenyl)ethan-1-one → 3'-[(E)-2-[4-[4-(4-Fluorophenyl)butoxy]phenyl]ethen-1-yl]-2'-hydroxyacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Hydroxy-3-iodophenyl)ethan-1-one | HCID 19606310 | — |
| Reactant | 4-[4-(4-Fluorophenyl)butoxy]-styrene | HCID 19606347 | — |
| Product | 3'-[(E)-2-[4-[4-(4-Fluorophenyl)butoxy]phenyl]ethen-1-yl]-2'-hydroxyacetophenone | HCID 19606327 | 70% |
Reaction Steps
Following the process described in example 20 (point D), starting from 4-[4-(4-fluorophenyl)butoxy]-styrene and 2'-hydroxy-3'-iodoacetophenone, the title compound was prepared, which was purified by chromatography through a silica gel column, eluting with petroleum ether:ethyl ether, 95:5 (70% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05990142 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-d15d39d0e76d4624a4cc4bebcbfcb452 |
| Source note | uspto-grants-1999_11 |