HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl 8-[(E)-2-[4-[4-(4-fluorophenyl)butoxy]phenyl]-ethen-1-yl]-4-oxo-4H-1-benzopyran-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | 3'-[(E)-2-[4-[4-(4-Fluorophenyl)butoxy]phenyl]ethen-1-yl]-2'-hydroxyacetophenone | HCID 19606327 | — |
| Product | Ethyl 8-[(E)-2-[4-[4-(4-fluorophenyl)butoxy]phenyl]-ethen-1-yl]-4-oxo-4H-1-benzopyran-2-carboxylate | HCID 19606308 | 65% |
Reaction Steps
Following the process described in example 1 (point A), starting from 3'-[(E)-2-[4-[4-(4-fluorophenyl)butoxy]phenyl]ethen-1-yl]-2'-hydroxy-acetophenone and diethyl oxalate, the title compound was prepared, which was purified by chromatography through a silica gel column, eluting with petroleum ether:chloroform, 8:2 (65% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05990142 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-9bc0e830048e4411bd4ff00aeb295f8c |
| Source note | uspto-grants-1999_11 |