Hydrochloric Acid → HCID 19605568, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-2 (0.3 g, 0.88 mmol) was dissolved in EtOAc (10 mL), cooled to -78° C. and saturated with HCl gas, warmed to 0° C. for 1 hour and concentrated to give ethyl 2-(2-nitro-4-aminophenoxy)acetic acid as a white solid that was coupled immediately (0.26 g, 0.88 mmol) to 1-5 (0.29 g, 0.95 mmol) as described for 5--5 to give 5-9 as a yellow solid after chromatography in a gradient of 40 to 100% EtOAc/hexanes.

Provenance & Evidence