Trifluoroacetic acid → HCID 70200487, compound

Participants

Reaction Steps

(4S,5R,6R)-5-Acetylamino-4-(tert-butoxycarbonylamino)-6-(methyl-propylcarbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid benzhydryl ester (0.10 g) was dissolved in dichloromethane (1 ml) and trifluoroacetic acid (1 ml) and left to stand at 23° C. for 3 hours. The solvent was removed in vacuo and the residue was triturated using diethyl ether (30 ml). The resulting solid was collected by filtration and dried to give the title compound as a white solid. (0.064 g): 1H NMR (250MHz, D2O) 5.99 (1H, m), 5.24 (1H, m), 4.52 (1H, m), 4.25 (1H, m), 3.59-3.18 (2H, m), 3.18+2.97 (3H, s), 2.02 (3H, s), 1.72-1.46 (2H, m), 0.87 (3H, m); Mass Analysis: C15H22F3N3O7. 0.25H2O. Required C, 43.12; H, 5.43; N, 10.06; Found C, 42.99; H, 5.60; N, 10.17; Mass Spec. (Low Resolution) MH+ =300.

Provenance & Evidence