HCID 86754848, compound → HCID 57128419, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (4S,5R,6R)-5-acetylamino-4-hydroxy-6-[(2-biphenyl-4-yl-ethyl)propylcarbamoyl]-5,6-dihydro-4H-pyran-2-carboxylic acid, methyl ester (0.89 g) water (5 ml) and triethylamine (5 ml) was heated at 50° C. for 6 hours. The solvent was then removed in vacuo and the residue was co-evaporated with dioxane (×3) to afford the title compound as an off white solid (0.87 g). 1H NMR (250 MHz, D6 -DMSO rotamers) 7.96 (1H, d, J=8 Hz), 7.60 (4H, m), 7.45 (2H, m), 7.33 (3H, m), 5.72 (1H, m), 5.15 (1H, m), 4.90 (1H, m), 4.25 (1H, m), 3.87 (1H, m), 3.60-2.95 (8H, m), 1.80+1.75 (3H, 2×s), 1.55 (1H, m), 1.46 (1H, m), 0.83 (3H, m). Mass analysis: C26H30N2O6. 1.0 H2O. 0.6 C6H15N Required: C, 65.20; H, 7.58; N, 6.68. Found: C, 65.40; H, 7.59; N, 6.44.

Provenance & Evidence