Acrylonitrile → Phosphinic acid, (2-cyanoethyl)methyl-, ethyl ester

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Reaction Steps

120 g (2.26 mol) of acrylonitrile are added dropwise over 12 hours at 160° C. to 324 g (3.0 mol) of methanephosphonous monoethylester with vigorous stirring and under an inert-gas atmosphere. The excess monoester is then distilled off at 0.4 mbar. The residue is distilled using a Vigreux column at 142-143° C. at 0.4 mbar, giving 330 g of ethyl 2-cyanoethylmethylphosphinate (refractive index nD22 : 1.4554). This corresponds to a yield of 90% of theory.

Provenance & Evidence