Acetoxyacetyl chloride → HCID 18429273, compound

HRID 1604168Notes

Reaction equation

[OH:1][CH:2]([C:5]1[C:10]([I:11])=[C:9]([NH2:12])[C:8]([I:13])=[C:7]([NH2:14])[C:6]=1[I:15])[CH2:3][OH:4].C([O:19][CH2:20][C:21](Cl)=[O:22])(=O)C>>[OH:1][CH:2]([C:5]1[C:6]([I:15])=[C:7]([NH:14][C:2](=[O:1])[CH2:3][OH:4])[C:8]([I:13])=[C:9]([NH:12][C:21](=[O:22])[CH2:20][OH:19])[C:10]=1[I:11])[CH2:3][OH:4]

Participants

Reactant 2

HCID 26297Acetoxyacetyl chloride

HCID 18429214HCID 18429214, compound

Product 1

HCID 18429273HCID 18429273, compound

Procedure

1-(1,2-Dihydroxyethyl)-3,5-diamino-2,4,6-triiodobenzene is acylated with acetoxyacetyl chloride using for example such a procedure as described in Example 4d. The crude product is then hydrolyzed analogous to Example 4e to give the final product. Purification of the crude product is carried out using preparative HPLC.

Sources & evidence

ORD record: ord-bf7687545af341fd9caf01b35d020429
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05993780

Reaction notes

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