Sodium Hydroxide → HCID 86754862, compound

HRID 1604175Notes

Reaction equation

HRID 1604175 reaction equation
C([O:4][CH2:5][CH2:6][N:7]([C:15]1[C:16]([I:42])=[C:17]([CH2:37][O:38]C(=O)C)[C:18]([I:36])=[C:19]([C:34]=1[I:35])[C:20]([NH:22][CH2:23][CH:24]([O:30]C(=O)C)[CH2:25][O:26]C(=O)C)=[O:21])[C:8](=[O:14])[CH2:9][O:10]C(=O)C)(=O)C.[OH-].[Na+]>CO>[OH:4][CH2:5][CH2:6][N:7]([C:15]1[C:16]([I:42])=[C:17]([CH2:37][OH:38])[C:18]([I:36])=[C:19]([C:34]=1[I:35])[C:20]([NH:22][CH2:23][CH:24]([OH:30])[CH2:25][OH:26])=[O:21])[C:8](=[O:14])[CH2:9][OH:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86754863HCID 86754863, compound

Product 1

HCID 86754862HCID 86754862, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-[N'-(2-acetoxyethyl)-acetoxyacetamido]-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide (2.76 g, 2.96 mmol) was dissolved in methanol (4 ml) at room temperature. An aqueous solution of sodium hydroxide (2M, 11.1 ml) was slowly added with efficient stirring. After 30 minutes, the pH of the solution was adjusted to 6 by the addition of a strongly acidic ion exchange resin (Amberlyst 15). The resin was filtered off and the solution was evaporated to a crystalline residue. The product was purified by preparative HPLC. Yield: 1.80 g (84%).

Workup

  1. additionthe pH of the solution was adjusted to 6 by the addition of a strongly acidic ion exchange resin (Amberlyst 15)
  2. filtrationThe resin was filtered off
  3. customthe solution was evaporated to a crystalline residue
  4. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-138e0dc83fc04e64b73cb66fa164336e
Source dataset
uspto-grants-1999_11
Patent number
US05993780

Reaction notes

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