HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetoxypropionyl Chloride → 5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetoxypropionyl Chloride | HCID 4547492 | — |
| Reactant | 3-Acetoxymethyl-5-(2,3-diacetoxypropylaminocarbonyl)-2,4,6-triiodoaniline | HCID 18429130 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide | HCID 18429188 | 100% |
Reaction Steps
5-Amino-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide (3.20 g, 4.3 mmol) was dissolved in dry dimethylacetamide (4 ml). 2-Acetoxypropionyl chloride (2.17 ml, 17.2 mmol) was then added dropwise with efficient stirring. Stirring was continued over night. After work up according to the procedure in Example 24i, 3.66 g (100%) of product was isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05993780 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-272904b41fa24ab3923bda52bff6be29 |
| Source note | uspto-grants-1999_11 |