1-Acetoxy-2-bromoethane → 5-[N'-(2-Acetoxyethyl)-2-acetoxypropionylamino]-3-acetoxymethyl-N-(2,3-di-acetoxypropyl)-2,4,6-triiodobenzamide

HRID 1604177Notes

Reaction equation

HRID 1604177 reaction equation
[C:1]([O:4][CH:5]([CH3:37])[C:6]([NH:8][C:9]1[C:10]([I:36])=[C:11]([CH2:31][O:32][C:33](=[O:35])[CH3:34])[C:12]([I:30])=[C:13]([C:28]=1[I:29])[C:14]([NH:16][CH2:17][CH:18]([O:24][C:25](=[O:27])[CH3:26])[CH2:19][O:20][C:21](=[O:23])[CH3:22])=[O:15])=[O:7])(=[O:3])[CH3:2].[C:38]([O:41][CH2:42][CH2:43]Br)(=[O:40])[CH3:39]>>[C:38]([O:41][CH2:42][CH2:43][N:8]([C:6](=[O:7])[CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH3:37])[C:9]1[C:10]([I:36])=[C:11]([CH2:31][O:32][C:33](=[O:35])[CH3:34])[C:12]([I:30])=[C:13]([C:28]=1[I:29])[C:14]([NH:16][CH2:17][CH:18]([O:24][C:25](=[O:27])[CH3:26])[CH2:19][O:20][C:21](=[O:23])[CH3:22])=[O:15])(=[O:40])[CH3:39]

Participants

3

Reactant 2

HCID 135641-Acetoxy-2-bromoethaneHCID 184291885-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide

Product 1

HCID 184292635-[N'-(2-Acetoxyethyl)-2-acetoxypropionylamino]-3-acetoxymethyl-N-(2,3-di-acetoxypropyl)-2,4,6-triiodobenzamideYield 95%

Procedure

5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide was alkylated with 2-bromoethyl acetate according to the general procedure described in Example 25a. After work up the product was isolated in 95% yield.

Workup

  1. customAfter work up the product was isolated in 95% yield

Sources & evidence

ORD record
ord-91734415db34421d9d2dcd419d98c2e4
Source dataset
uspto-grants-1999_11
Patent number
US05993780

Reaction notes

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