1-Acetoxy-2-bromoethane → HCID 18429303, compound

HRID 1604186Notes

Reaction equation

HRID 1604186 reaction equation
[CH3:1][C:2]1([CH3:38])[O:6][CH:5]([C:7]([NH:9][C:10]2[C:11]([I:37])=[C:12]([CH2:32][O:33][C:34](=[O:36])[CH3:35])[C:13]([I:31])=[C:14]([C:29]=2[I:30])[C:15]([NH:17][CH:18]([CH2:24][O:25][C:26](=[O:28])[CH3:27])[CH2:19][O:20][C:21](=[O:23])[CH3:22])=[O:16])=[O:8])[CH2:4][O:3]1.[C:39]([O:42][CH2:43][CH2:44]Br)(=[O:41])[CH3:40]>>[C:39]([O:42][CH2:43][CH2:44][N:9]([C:10]1[C:11]([I:37])=[C:12]([CH2:32][O:33][C:34](=[O:36])[CH3:35])[C:13]([I:31])=[C:14]([C:29]=1[I:30])[C:15]([NH:17][CH:18]([CH2:24][O:25][C:26](=[O:28])[CH3:27])[CH2:19][O:20][C:21](=[O:23])[CH3:22])=[O:16])[C:7]([CH:5]1[CH2:4][O:3][C:2]([CH3:38])([CH3:1])[O:6]1)=[O:8])(=[O:41])[CH3:40]

Participants

3

Reactant 2

HCID 135641-Acetoxy-2-bromoethaneHCID 18429162HCID 18429162, compound

Product 1

HCID 18429303HCID 18429303, compoundYield 83%

Procedure

The alkylation of 5-(2,2-dimethyl-1,3-dioxolane-4-carboxamido)-3-acetoxymethyl-N-(1,3-diacetoxyprop-2-yl)-2,4,6-triiodobenzamide with 2-bromoethyl acetate was performed according to the procedure of Example 30a. The crude product was isolated in 83% yield.

Sources & evidence

ORD record
ord-341842cca1324349af65247308b0bb8c
Source dataset
uspto-grants-1999_11
Patent number
US05993780

Reaction notes

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