Ethanolamine → 5-Amino-3-acetoxymethyl-N-(2-hydroxyethyl)-2,4,6-triiodobenzamide

HRID 1604187Notes

Reaction equation

[NH2:1][C:2]1[C:3]([I:18])=[C:4]([CH2:13][O:14][C:15](=[O:17])[CH3:16])[C:5]([I:12])=[C:6]([C:10]=1[I:11])[C:7](Cl)=[O:8].[CH2:19]([CH2:21][NH2:22])[OH:20]>>[NH2:1][C:2]1[C:3]([I:18])=[C:4]([CH2:13][O:14][C:15](=[O:17])[CH3:16])[C:5]([I:12])=[C:6]([C:10]=1[I:11])[C:7]([NH:22][CH2:21][CH2:19][OH:20])=[O:8]

Participants

Reactant 2

HCID 700Ethanolamine

HCID 184293385-Amino-3-acetoxymethyl-2,4,6-triiodobenzoyl chloride

Product 1

HCID 184292535-Amino-3-acetoxymethyl-N-(2-hydroxyethyl)-2,4,6-triiodobenzamide

Procedure

5-Amino-3-acetoxymethyl-2,4,6-triiodobenzoyl chloride was reacted with ethanolamine according to the general procedure in Example 24g. The yield of isolated product was 98%.

Sources & evidence

ORD record: ord-2e98ab2c9028401fa364439aa7802af6
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05993780

Reaction notes

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