Acetone → HCID 19602485, compound

Participants

Reaction Conditions

Reaction Steps

150 mg of (3RS,5RS)-3-[N-(Azidoacetyl)aminomethyl]-4-oxa-1-azabicyclo[3.2.0]heptan-7-one was dissolved in 10 ml of Acetone and Acetylene was bubbled at -78° C. for 5 minutes. The reaction mixture was heated at 60-70° C. in seal tube for 17 hrs. After reaction completed, solvent was removed in vacuo and the residue was purified by silicagel column chromatography (Ethyl acetate+Acetone 3:1). The title compound was obtained as oil.

Provenance & Evidence