Dicyclohexylcarbodiimide → HCID 19602479, compound

Participants

Reaction Steps

600 mg of (3RS,5RS)-3-Azidomethyl-4-oxa-1-azabicyclo[3.2.0]heptan-7-one was hydrogenated with 1.0 g of 10% Palladium on activated carbon in Ethyl acetate at 50 psi for 1 hr. After removal of catalyst by filtration, 360 mg (3.6 mmol) of 4-Pentenoic acid and 300 mg (1.8 mmol) of 1,3-Dicyclohexyl carbodiimide were added under ice-cooling. The reaction mixture was then stirred at room temperature for 2 hrs. Resulted solid was filtered off and the filtrate was concentrated in vacuo. The residue was purified by flash silicagel column using Hexane-Ethyl acetate (1:1) as eluent and the title compound was obtained as oil.

Provenance & Evidence