Piperidine → HCID 53725566, compound

Participants

Reaction Steps

A stirred solution of 5-(3-chloropropyl)-3-phenylmethyleneamino-2-oxazolidinone (2.7 g, 0.0101 mole), dimethylformamide (75 ml) and piperidine (2.15 g, 0.0253 mole, 2.5 eq.) is heated to reflux. Reflux is maintained for 2 hours. After cooling, the solution is concentrated under reduced pressure to a solid-oily residue. This residue is suspended in H2O (200 ml) then extracted with ethyl acetate (3×100 ml). The ethyl acetate is dried over MgSO4, filtered, then concentrated under reduced pressure to an oily-solid residue. This residue is triturated in hexane by stirring 1 hours. The solid is collected and air-dried giving 1.67 g (0.0053 mole) of 3-phenylmethyleneamino-5-[3-(1-piperidinyl)propyl]-2-oxazolidinone.

Provenance & Evidence