反应详情

To 150 ml of 20% hydrous DMSO were added 6.15 g of 3,4-dichlorobenzyl cyanide, 8.13 g of 4-bromo-3,5-dichloronitrobenzene and 1.50 g of sodium hydroxide. The reaction was allowed to proceed for one hour at temperatures ranging from 60 to 70° C. After completion of the reaction, DMSO was removed, and the residue was dissolved in 50 ml of toluene. The solution was washed with water, dried and concentrated. To the concentrate was added ethyl alcohol-to cause crystallization to afford the titled compound in a yield of 67%, m.p. 171-172° C.

1. customranging from 60 to 70° C
2. customwas removed
3. dissolutionthe residue was dissolved in 50 ml of toluene
4. washThe solution was washed with water
5. customdried
6. concentrationconcentrated
7. additionTo the concentrate was added ethyl alcohol-
8. customcrystallization