Trifluoromethylsulfonamide → HCID 19602614, compound

HRID 1604360Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH2:22][CH:23]2[CH2:25][CH2:24]2)=[C:6]([CH:20]=1)[CH2:7][N:8]([C:11]1[N:16]=[N:15][C:14]([C:17](O)=[O:18])=[CH:13][CH:12]=1)[CH2:9][CH3:10].[F:26][C:27]([F:33])([F:32])[S:28]([NH2:31])(=[O:30])=[O:29]>>[F:26][C:27]([F:33])([F:32])[S:28]([NH:31][C:17]([C:14]1[N:15]=[N:16][C:11]([N:8]([CH2:7][C:6]2[CH:20]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[O:21][CH2:22][CH:23]2[CH2:25][CH2:24]2)[CH2:9][CH3:10])=[CH:12][CH:13]=1)=[O:18])(=[O:30])=[O:29]

Participants

Reactant 2

HCID 79001Trifluoromethylsulfonamide

HCID 22622548HCID 22622548, compound

Product 1

HCID 19602614HCID 19602614, compoundYield 18%

Procedure

The title compound was prepared from 6-[N-(5-chloro-2-cyclopropylmethoxybenzyl)-N-ethylamino]pyridazine-3-carboxylic acid (example 22) and trifluoromethanesulphonamide using a similar method to that of example 7. (Yield 18%). m.p. 150°-dec.

Sources & evidence

ORD record: ord-3c6740bb526e445fbb15abf81f779f62
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05994353

Reaction notes

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