3-Bromo-1,1,1-Trifluoro-2-Propanol → n-Butyl 6-[N-(5-bromo-2-(2-hydroxy-3,3,3-trifluoropropoxy)benzyl)-N-ethylamino]pyridazine-3-carboxylate

HRID 1604384Notes

Reaction equation

HRID 1604384 reaction equation
Br[CH2:2][CH:3]([OH:8])[C:4]([F:7])([F:6])[F:5].[Br:9][C:10]1[CH:11]=[CH:12][C:13]([OH:33])=[C:14]([CH:32]=1)[CH2:15][N:16]([C:19]1[N:24]=[N:23][C:22]([C:25]([O:27][CH2:28][CH2:29][CH2:30][CH3:31])=[O:26])=[CH:21][CH:20]=1)[CH2:17][CH3:18]>>[Br:9][C:10]1[CH:11]=[CH:12][C:13]([O:33][CH2:2][CH:3]([OH:8])[C:4]([F:7])([F:6])[F:5])=[C:14]([CH:32]=1)[CH2:15][N:16]([C:19]1[N:24]=[N:23][C:22]([C:25]([O:27][CH2:28][CH2:29][CH2:30][CH3:31])=[O:26])=[CH:21][CH:20]=1)[CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 2206323-Bromo-1,1,1-Trifluoro-2-PropanolHCID 22622486butyl 6-[N-(5-bromo-2-hydroxybenzyl)-N-ethylamino]pyridazine-3-carboxylate

Product 1

HCID 22622518n-Butyl 6-[N-(5-bromo-2-(2-hydroxy-3,3,3-trifluoropropoxy)benzyl)-N-ethylamino]pyridazine-3-carboxylate

Procedure

The title compound was prepared by reacting 3-bromo-1,1,1-trifluoropropan-2-ol and butyl 6-[N-(5-bromo-2-hydroxybenzyl)-N-ethylamino]pyridazine-3-carboxylate using a similar method to that of reference example 4.

Sources & evidence

ORD record
ord-06b2d39c43ae45c69ca2820ecc92d4d2
Source dataset
uspto-grants-1999_11
Patent number
US05994353

Reaction notes

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