3-Bromo-1,1,1-Trifluoro-2-Propanol → 6-[N-(5-Bromo-2-(3,3,3-trifluoro-2-hydroxypropoxy)benzyl)-N-ethylamino]-3-cyanopyridazine

HRID 1604390Notes

Reaction equation

HRID 1604390 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:20])=[C:6]([CH:19]=1)[CH2:7][N:8]([C:11]1[N:16]=[N:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=1)[CH2:9][CH3:10].[F:21][C:22]([F:28])([F:27])[CH:23]([OH:26])[CH2:24]Br>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:20][CH2:24][CH:23]([OH:26])[C:22]([F:28])([F:27])[F:21])=[C:6]([CH:19]=1)[CH2:7][N:8]([C:11]1[N:16]=[N:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=1)[CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 2206323-Bromo-1,1,1-Trifluoro-2-PropanolHCID 226225146-[N-(5-Bromo-2-hydroxybenzyl)-N-ethylamino]-3-cyanopyridazine

Product 1

HCID 226224946-[N-(5-Bromo-2-(3,3,3-trifluoro-2-hydroxypropoxy)benzyl)-N-ethylamino]-3-cyanopyridazine

Procedure

The title compound was prepared by reacting 6-[N-(5-bromo-2-hydroxybenzyl)-N-ethylamino]-3-cyanopyridazine with 1,1,1-trifluoro-3-bromo-propan-2-ol using a method similar to that of reference example 4.

Sources & evidence

ORD record
ord-8cd8a96c9745433e9e303df85bca95c8
Source dataset
uspto-grants-1999_11
Patent number
US05994353

Reaction notes

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