N-methyl-2-pyrrolidone → HCID 22622550, compound

Participants

Reaction Steps

N-Ethyl 5-chloro-2-(cyclobutylmethoxy)benzylamine (2.1 g, 8.3 mmol) was coupled to the 3-chloro-5-cyanopyridazine (1.3 g, 8.25 mmol) with sodium hydrogen carbonate (0.71 g. 8.45 mmol) in NMP (10 ml) in a similar method to that of reference example 18. The title compound was purified by MPLC (dichloromethane, 1% MeOH/dichloromethane) (2.3 g, 78%) to give a solid.

Provenance & Evidence