Pyridinium chloride → HCID 67557366, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of anhydrous pyridine hydrochloride (0.289 g, 2.50 mmol) and (±)-trans-3-(4-fluorophenyl)-7-methoxy-4-(4-(2-pyrrolidinoethoxy)phenyl)-chromane (0.11 g, 0.25 mmol) was heated to 135° C. for 18 h. The resulting dark brown solid was dissolved in a mixture of methanol (10 ml), water (50 ml) and sodium hydrogen carbonate solution (5 ml), and the product extracted into 9:1 dichloromethane /methanol (3×50 ml). The combined extracts were washed with brine, dried over magnesium sulfate and evaporated to an orange gum. The product was purified by column chromatography on silica gel 60, with 5% methanol in dichloromethane eluent, giving the purified product as a colourless wax.

Provenance & Evidence