Hydrochloric Acid → HCID 4308572, compound

Participants

Reaction Steps

To a solution of n-butylamine (99 mL, 1.0 mol) in CH2Cl2 (300 mL) was added 2-furoyl chloride (33.0 mL, 0.335 mol) dropwise at 0-5° C. with stirring. The reaction mixture was stirred for additional 2 h at 0-5° C. and overnight at room temperature. The solution was poured into a mixture of wet-ice (200 g) and 37% HCl (50 mL). After separation, the organic layer was washed with 2×200 mL water, dried over Na2SO4 and filtered. Removal of solvent provided the title compound (49.59 g, 88.6% yield) as a white solid, m.p.=43.8° C. (Rf=0.53 on a silica gel plate using EtOAc as an eluant). This product was used without further purification.

Provenance & Evidence