4-Fluorobenzoyl chloride → HCID 15435726, compound

HRID 1604478Notes

Reaction equation

HRID 1604478 reaction equation
[NH2:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:1][CH:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3]2)=[O:17])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 123445(+-)-1-Aminoindan

Product 1

HCID 15435726HCID 15435726, compound

Procedure

The title compound was prepared from (rac)-1-aminoindan (1.7 g, 12.85 mmole) and 4-fluorobenzoyl chloride (2.24 g, 14.1 mmole) as in Ex. 52; 1.71 g(6.7 mmole, 52%), mp: 109-10° C.

Sources & evidence

ORD record
ord-b0b847067e96498f9221fa819b349175
Source dataset
uspto-grants-1999_11
Patent number
US05994408

Reaction notes

Loading…