Dichloromethane → HCID 22113128, compound

Participants

Reaction Steps

To a suspension of 8-(2,6-dichloro-3-nitrobenzyloxy)-4-methoxy-2-methylquinoline (1.75 g) in methanol (17 ml) was added tin (II) chloride (3.37 g) at ambient temperature. The mixture was refluxed for 1 hour. After cooling, the mixture was adjusted to pH 10 with 1 N sodium hydroxide solution. To this mixture was added dichloromethane (50 ml) and the precipitate was removed by filtration. The filtrate was extracted with dichloromethane twice. The organic layer was washed with water and brine. After dried over magnesium sulfate, the solvent was removed in vacuo to give 8-(3-amino-2,6-dichlorobenzyloxy)-4-methoxy-2-methylquinoline (1.16 g) as a colorless powder.

Provenance & Evidence