Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | 4-Chloro-8-hydroxy-2-methylquinoline | HCID 12219722 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 19603260 | HCID 19603260 | 57% |
Reaction Steps
A mixture of 4-chloro-8-hydroxy-2-methylquinoline (500 mg), N,N-dimethylethylenediamine (341 mg) and phenol (486 mg) was heated at 125° C. for 18 hours. After cooling the reaction mixture, acetone (5 ml) was added thereto. The precipitates were collected by filtration and recrystallized from acetonitrile to give 4-(2-dimethylaminoethylamino)-8-hydroxy-2-methylquinoline hydrochloride (415 mg)) as brown crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05994368 |
|---|
| Source dataset | uspto-grants-1999_11 |
|---|
| ORD ID | ord-1062b682bf0e4e9db2aa1dae63a3126d |
|---|
| Source note | uspto-grants-1999_11 |
|---|
