Sodium Hydroxide → HCID 22593738, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl (E)-3-[6-(N-methyl-N-acetylamino)pyridin-3-yl]acrylate (110 mg) in methanol (3 ml) was added 1N sodium hydroxide solution (1.1 ml) at ambient temperature and the mixture was stirred at 50° C. for 4 hours. The reaction mixture was evaporated in vacuo and was dissolved in water. The solution was adjusted to pH 6 with 1N hydrochloric acid, and the precipitate was cooled by vacuum filtration to give (E)-3-[6-(methylamino)pyridin-3-yl]acrylic acid (72 mg) as a powder.

Provenance & Evidence