Triethylamine → HCID 53942881, compound

Participants

Reaction Steps

To a mixture of 10% trimethylsilyldiazomethane in hexane (4.2 ml) and triethylamine (527 mg) in tetrahydrofuranacetonitrile chloride hydrochloride (500 mg) in an ice water bath. The mixture was stirred for 7 hours in an ice water bath and allowed to stand for 18 hours at 0° C., then evaporated in vacuo. Saturated aqueous sodium bicarbonate solution was added to the residue and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over magnesium sulfate. Evaporation of the solvent gave crude 3-diazoacetyl-2-methylpyridine as an yellow oil.

Provenance & Evidence