Hydrochloric Acid → HCID 10769547, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-[2,6-dichloro-3-[N-[(E)-3-(6-ethoxycarbonylpyridin-3-yl)acryloylglycyl]-N-methylamino]benzyloxy]-2-methylquinoline (2.07 g) in ethanol (20 ml) was added 1N sodium hydroxide solution (3.75 ml) at ambient temperature. The mixture was stirred for 3 hours at 60° C. The reaction mixture was adjusted to pH 4 with 1N hydrochloric acid and concentrated. The residue was purified by flash chromatography (dichloromethane--methanol) to give 8-[3-[N-[(E)-3-(6-carboxypyridin-3-yl)acryloylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline (1.71 g) as an amorphous powder.

Provenance & Evidence