Water → 2-Methylquinoline

Participants

Reaction Steps

A mixture of 8-[3-[N-(bromoacetylglycyl)-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline (80 mg) 5-amino-1,3,4-thiadiazole-2-thiol (24 mg), potassium carbonate (42 mg) in dimethylformamide (2 ml) was stirred for 30 minutes at ambient temperature. To the mixture was added water, and the mixture was extracted with ethyl acetate twice. Combined organic layers were washed with water three times, dried over magnesium sulfate and concentrated. The residue was pulverized from diethyl ether to give 8-[3-[N-(5-amino-1,3,4-thiadiazol-2-ylthio)acetylglycol]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline (25 mg) as a solid.

Provenance & Evidence