HCID 19603510, compound → HCID 17812572, compound

Participants

Reaction Steps

A mixture of 8-benzyloxy-2-methyl-4-vinylquinoline (200 mg) and palladium(II) hydroxide (40 mg) in a mixture of ethanol (1.5 ml) and dioxane (1.5 ml) was stirred for 9 hours at ambient temperature under hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated. The residue was purified by flash chromatography (Ethyl acetate:n-hexane=1:2, V/V) to give 4-ethyl-8-hydroxy-2-methylquinoline (66 mg) as brown oil.

Provenance & Evidence