Water → HCID 54150500, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8-[3-[N-[4-(4-bromobutyramido)-3-methylcinnamoylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline (110 mg) in N,N-dimethylformamide was added potassium carbonate (64 mg) and the mixture was stirred for 2 hours at 50° C. The mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried and concentrated in vacuo. The residue was purified by preparative thin-layer chromatography (dichloromethane-methanol) to give 8-[2,6-dichloro-3-[N-methyl-N-[3-methyl-4-(2-oxopyrrolidin-1-yl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline (72 mg) as an amorphous powder.

Provenance & Evidence