Water → HCID 19603298, compound

Participants

Reaction Steps

To a solution of 8-[3-(N-acetoxyacetyl-n-methylamino)-2,6-dichlorobenzyloxy]-2-methylquinoline (640 mg) in methanol (6.4 ml) was added potassium carbonate (395 mg), and the mixture was stireed for 2 hours at ambient temperature. To the mixture was added chloroform and water, the organic layer was washed with water and brine, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by chromatography on silica gel (chloroform:ethyl acetate=3.1, V/V) to give 8-[2,6-dichloro-3-(N-hydroxyacetyl-N-methylamino)benzyloxy]-2-methylquinoline (580 mg) as colorless amorphous.

Provenance & Evidence