HCID 19603302, compound → HCID 178422702, compound

Participants

Reaction Conditions

Reaction Steps

to asolution of 8-[2,6-dichloro-3-[N-methyl-N-(4-aminocinnamoylglycyl)amino]benzyloxy]-2-methylquinoline (50 mg) in ethanol (2 ml) were added N,N-bis(tert-butoxycarbonyl)-S-methoxyisothiourea (28 mg) and mercury (II) oxide (21 mg) at ambient temperature and stirred for 1 hours at 40° C. The reaction mixture was filtered and the filtrate was evaporated in vacuo. The residue was purified by preparative thin-layer chromatography (8% solution of methanol in chloroform) to give 8-[2,6-dichloro-3-[N-[4-[2,3-bis(tert-butoxycarbonyl)guanidino]-cinnamoylglycyl]-N-methylamino]benzyloxy]-2-methylquinoline (60 mg) as an amorphous powder.

Provenance & Evidence