Sodium Hydroxide → HCID 19603725, compound

Participants

Reaction Steps

A solution of methyl 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]methyl}indole-2-carboxylate (0.86 g) and sodium hydroxide (0.77 g) in a mixture of water (10 ml) and ethanol (20 ml) was stirred under reflux for 2 hours. After removal of solvents, the residue was dissolved into water and the solution was acidified with diluted hydrochloric acid to pH 3. The resulting precipitates were collected by filtration and dried in vacuo to give 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]methyl}indole-2-carboxylic acid (0.80 g).

Provenance & Evidence