Potassium Carbonate → HCID 19603714, compound

Participants

Reaction Steps

A mixture of 4-tert-butyl-2-[5-(chloromethyl)benzofuran-2-yl]thiazole (0.36 g), benzyl indazole-3-carboxylate (0.30 g) and potassium carbonate (0.33 g) in methylethylketone (20 ml) was stirred under reflux for 7 hours. After being cooled to room temperature, the mixture was filtered and the filtrate was concentrated under reduced pressure. The syrup was subjected to column chromatography on silica gel and eluted with a mixture of n-hexane and ethyl acetate. The fractions containing the objective compounds were combined and concentrated under reduced pressure to give benzyl 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]methyl}-1H-indazole-3-carboxylate (0.40 g) and benzyl 2-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]methyl}-2H-indazole-3-carboxylate (0.12 g).

Provenance & Evidence