Formamide → HCID 19603766, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of benzyl 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]methyl}-1H-indazole-3-carboxylate (0.35 g), sodium methoxide (0.1 g) and formamide (4 ml) in tetrahydrofuran (2 ml) was stirred at 100° C. for 2 hours. After being cooled to room temperature, the mixture was concentrated under reduced pressure. Water was added to the residue and the resulting precipitates were collected by filtration and washed with a mixture of n-hexane and diisopropyl ether to give 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]methyl}-1H-indazole-3-carboxamide. (0.22 g).

Provenance & Evidence