HCID 19603776, compound → HCID 19603713, compound

Participants

Reaction Steps

5-Benzyloxy-1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]methyl}-1H-indazole-3-carboxamide (0.122 g) was added to a solution (1 M) of borontribromide in dichloromethane (0.57 ml) under ice-cooling and then the mixture was stirred at room temperature for 1.5 hours. The mixture was concentrated under reduced pressure and the residue was partitioned between aqueous sodium hydrogen carbonate solution and ethyl acetate. The organic layer was separated, dried over magnesium sulfate and concentrated under reduced pressure to give 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]methyl}-5-hydroxy-1H-indazole-3-carboxamide (0.08 g).

Provenance & Evidence