Hydrochloric Acid → HCID 19603701, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-tert-butyl-2-[5-(bromoacetyl)benzofuran-2-yl]thiazole (0.20 g), 3-cyanoindole (75 mg) and potassium carbonate (146 mg) in methylethylketone (3 ml) was stirred at 40° C. for 2 hours. After being cooled to room temperature, the mixture was poured into ice-water and the mixture was acidified with diluted hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was collected by trituration with diisopropyl ether to give -1-{2-[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]-2-oxoethyl}indole-3-carbonitrile (0.20 g).

Provenance & Evidence