Sodium Hydroxide → HCID 23699779, compound

HRID 1604695Notes

Reaction equation

HRID 1604695 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]4[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[C:22]=4[O:23][CH:24]([CH3:28])[C:25]([OH:27])=[O:26])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+:36]>CO>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]4[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[C:22]=4[O:23][CH:24]([CH3:28])[C:25]([O-:27])=[O:26])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:2])([CH3:3])[CH3:4].[Na+:36]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19603688HCID 19603688, compound

Product 1

HCID 23699779HCID 23699779, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-{2-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yloxy]methyl}-6-methoxyphenoxy}propionic acid (583 mg) in methanol (5 ml) was added 1N sodium hydroxide solution (1.21 ml). The solution was concentrated under reduced pressure and the residue was dissolved in water (5 ml) and lyophilized to give sodium 2-{2-{[2-(tert-butylthiazol-2-yl)benzofuran-5-yloxy]methyl}-6-methoxyphenoxy}propionate (580 mg) as an amorphous solid.

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. dissolutionthe residue was dissolved in water (5 ml)

Sources & evidence

ORD record
ord-5413748223f74806ad442c6e270297d5
Source dataset
uspto-grants-1999_11
Patent number
US05994378

Reaction notes

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