1,4,7,10-Tetraazacyclododecane → HCID 23687561, compound

Participants

Reaction Conditions

Reaction Steps

10 g (58.08 mmol) of 1,4,7,10-tetraazacyclododecane, 4.85 g (116.16 mmol) of LiCl and 40.0 g (278.4 mmol) of 4,4-dimethyl-3,5,8-trioxabicyclo[5,1,0]octane are suspended in 40 ml of isopropanol and refluxed for 60 hours. Then, the reaction mixture is mixed with 30 ml of isopropanol and cooled slowly to 0° C. The crystals that are obtained are suctioned off, washed with 30 ml of methyl-tert-butyl ether and dried in a vacuum. 20.7 g (71% of theory) of 1,7-bis(6-hydroxy-2,2-dimethyl-1,3-dioxepan-5-yl)-1,4,7,10-tetraazacyclododecane LiCl complex is obtained as white crystals.

Provenance & Evidence