Cyclohexene oxide → HCID 86754875, compound

Participants

Reaction Conditions

Reaction Steps

10 g (58.08 mmol) of 1,4,7,10-tetraazacyclododecane, 4.85 g (116.16 mmol) of LiCl and 56.5 g (580.0 mmol) of cyclohexene oxide (7-oxabicyclo[4.1.0]heptane) are suspended in 20 ml of isopropanol and refluxed for 20 hours. Then, the reaction mixture is mixed with 30 ml of isopropanol and slowly cooled to 0° C. The crystals that are obtained are suctioned off, washed with 30 ml of methyl-tert-butyl ether and dried in a vacuum. 19.5 g (82% of theory) of 1,7-bis(6-hydroxycyclohexyl)-1,4,7,10-tetraazacyclododecane LiCl complex is obtained as white crystals. Melting point 170-178° C.

Provenance & Evidence