Chlorine → HCID 19604208, compound

HRID 1604712Notes

Reaction equation

HRID 1604712 reaction equation
ClCl.Cl[C:4]1([C:14](=[O:21])[CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])[CH:9]=[C:8]([Cl:10])[C:7](=[O:11])[NH:6][CH:5]1OC>CO>[Cl:10][C:8]1[C:7](=[O:11])[NH:6][CH:5]=[C:4]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])[CH:9]=1

Participants

4

Reactant 2

HCID 24526ChlorineHCID 19604218HCID 19604218, compound

Product 1

HCID 19604208HCID 19604208, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was also obtained in 28 percent yield by chlorinating 5-succinoyl-2-pyridone methyl ester (obtained analogously to Example 7 from 5-succinoyl-2-pyridone and methanol/sulfuric acid) using chlorine in methanol. The main product obtained (70 percent yield) was methyl 4-(3,5-dichloro-2-methoxy-6-oxo-1,2,3,6-tetrahydropyridin-3-yl)-4-oxobutyrate, which was characterized by the following data:

Workup

  1. customThe main product obtained (70 percent yield)

Sources & evidence

ORD record
ord-6af7e8dee7c24788bfee9d3a9a49cddc
Source dataset
uspto-grants-1999_11
Patent number
US05994540

Reaction notes

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