Ammonia → HCID 11769856, compound

HRID 1604714Notes

Reaction equation

HRID 1604714 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]2[O:12][C:11](=[O:13])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH3:14]>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]([OH:12])[CH2:9][CH2:10][C:11]([NH2:14])=[O:13])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 10954511HCID 10954511, compound

Product 1

HCID 11769856HCID 11769856, compound

Conditions

Temperature
45 °C

Procedure

3.6 g of 5-(6-chloropyridin-3-yl)tetrahydrofuran-2-one (prepared as described in Example 15) was dissolved in 30 ml of 25 percent aqueous ammonia solution and the mixture was heated at 45° C. for 1.5 hours. The solution was evaporated in vacuo. The oily residue (4.65 g) was dried in vacuo over phosphorus pentoxide. The product yield was 3.9 g (approximately 100%) of rubber-like product. Other data concerning the product was:

Workup

  1. customThe solution was evaporated in vacuo
  2. dry with materialThe oily residue (4.65 g) was dried in vacuo over phosphorus pentoxide

Sources & evidence

ORD record
ord-8e01e98198184634b22df0d53ef32c97
Source dataset
uspto-grants-1999_11
Patent number
US05994540

Reaction notes

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