Water → HCID 53973457, compound

Participants

Reaction Steps

30.4 g. of salicylic acid hydrazide are dissolved in 200 ml of dimethylacetamide and 16 g of pyridine and 22 g of chloroformic acid ethyl ester are then added simultaneously over the course of 30 minutes. Thereafter the reaction mixture is heated to 80°-90° C for 5 hours whilst stirring and is then cooled to room temperature, and about 500 ml of water are added carefully. Hereupon the N-salicyloyl-hydrazine-carboxylic acid ethyl ester produced (Stabiliser No. 1) separates out as a micro-crystalline precipitate. The compound is isolated and is purified by washing with water and recrystallised from ethanol. Melting point 126° C.

Provenance & Evidence