HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 2-methoxy-N-methyl-3-morpholino-2-(2-pyridyl)thiopropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | alpha-methoxy-N-methyl-2-pyridylthioacetamide | HCID 15581955 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-methoxy-N-methyl-3-morpholino-2-(2-pyridyl)thiopropanamide | HCID 53846077 | — |
Reaction Steps
A solution of 1.96 g. (0.01 mole) of 2-methoxy-N-methyl-2-(2-pyridyl)thioacetamide in 20 ml. of methanol is treated with 1.3 g. (0.015 mole) of morpholine and 0.45 g. (0.015 mole) of formaldehyde. The mixture is refluxed for 48 hours. The solvents are removed in vacuo. The residue is recrystallized twice from 2-propanol to give 2-methoxy-N-methyl-3-morpholino-2-(2-pyridyl)thiopropanamide, m.p. 128°-132°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03948892 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-612e07b69dc644d0826275c4018fa372 |
| Source note | uspto-grants-1976_04 |