HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 21486904, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Methoxy-2-(2-pyridyl)acetyl chloride hydrochloride | HCID 21486914 | — |
| Reactant | (RS)-Methoxy-pyridin-2-yl-acetic acid | HCID 21905598 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 21486904 | HCID 21486904 | — |
Reaction Steps
Alternatively, 2-methoxy-N,N-dimethyl-2-(2-pyridyl)acetamide is prepared by the following procedure. 2-Methoxy-2-(2-pyridyl)acetyl chloride hydrochloride, 22 g., [prepared by reacting 2-methoxy-2-(2-pyridyl)acetic acid in benzene with thionyl chloride] in 100 ml. of chloroform is added dropwise and with cooling to 50 g. of dimethylamine in 100 ml. of chloroform. The mixture is stirred for 4 hours, then 50 ml. of 5% aqueous sodium hydroxide is added and the chloroform solution is dried and concentrated to give 2-methoxy-N,N-dimethyl-2-(2-pyridyl)acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03948892 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-1584e8b0728942a6a3809184e50f33e2 |
| Source note | uspto-grants-1976_04 |