反应详情

Phosphorus pentasulfide (4 g.) is added to 9.7 g. of 2-methoxy-N,N-dimethyl-2-(2-pyridyl)acetamide in 25 ml. of pyridine. The mixture is heated on a steam bath for 2 hours, then 250 ml. of water and 10 ml. of 5% aqueous sodium hydroxide solution are added. The mixture is extracted with chloroform and the extracts are dried and concentrated and the residue is recrystallized to give 2-methoxy-N,N-dimethyl-2-(2-pyridyl)-thioacetamide.

1. temperatureThe mixture is heated on a steam bath for 2 hours
2. extractionThe mixture is extracted with chloroform
3. customthe extracts are dried
4. concentrationconcentrated
5. customthe residue is recrystallized